Recent studies revealed that hexogen hormone replacement may cause undesirable effects in times ahead. Therefore patients are reluctant to use hormone therapy. Recent years, a favorite treatment model which comprises of the agents selectively acting in tissues sensitive to estrogens is gaining acceptance. Remifemin offers the most efficient and most safe therapy in this group. Remifemin relieves menopause symptoms such as hot flashes, sweating, nervousness and sleep disturbances with its selective tissue activity.